化工社化工社化学信息打印报告 · 仅供科研参考
3-氨基-2,6-二甲基吡啶 → 2-{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N-(2,6-dimethyl-pyridin-3-yl)-acetamide
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 3-氨基-2,6-二甲基吡啶 | HCID 76964 | — |
| 反应物 | {4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-acetic acid hydrochloride | HCID 25262898 | — |
| 产物 | 2-{4-[(4S,5R)-2-(6-tert-Butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-N-(2,6-dimethyl-pyridin-3-yl)-acetamide | HCID 57670014 | — |
反应步骤
In a manner analogous to the method described in examples 99, {4-[(4S,5R)-2-(6-tert-butyl-4-ethoxy-pyridin-3-yl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl]-piperazin-1-yl}-acetic acid hydrochloride (example 94) was coupled with 2,6-dimethyl-pyridin-3-ylamine (Alfa) to give the title compound. HR-MS (ES, m/z) calculated for C42H50Cl2N7O3 [(M+H)+] 770.3347, observed 770.3351.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US08513239B2 |
| 来源数据集 | uspto-grants-2013_08 |
| ORD ID | ord-e686bfce76a843a28848cd39cd3063b5 |
| 来源说明 | uspto-grants-2013_08 |