聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯] → 5-苯基-2-三苯基甲基四唑

HRID 1902

反应方程式

HRID 1902 反应方程式
[C:1]1([C:7]2[NH:11][N:10]=[N:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.[C:19]1([C:25](Cl)([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.O>CC(C)=O.O1CCCC1>[C:1]1([C:7]2[N:8]=[N:9][N:10]([C:25]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)([C:32]3[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=3)[C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=3)[N:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参与物

7

反应物 4

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]HCID 6456三苯基氯甲烷HCID 8471三乙胺HCID 178418369HCID 178418369，化合物

产物 1

HCID 32929595-苯基-2-三苯基甲基四唑收率 100%

试剂、催化剂与溶剂 2

HCID 180丙酮溶剂HCID 8028四氢呋喃溶剂

实验过程

To a suspension of 5.0 g (34.2 mmol) of 5-phenyltetrazole in 55 mL of acetone was added 5.0 mL of triethylamine (3.6 g, 35.6 mmol, 1.04 eq). After 15 minutes, a solution of 10.0 g of triphenylmethyl chloride (35.9 mmol, 1.05 eq) in 20 mL of tetrahydrofuran was added and the mixture stirred at room temperature for one hour. Water (75 mL) was slowly added and the mixture stirred for one hour at room temperature. The product was collected by filtration, washed with 75 mL of water and dried at 60° C. under vacuum to give 13.3 g (34.2 mmol, 100%) of the product.

后处理

  1. stirringthe mixture stirred for one hour at room temperature
  2. filtrationThe product was collected by filtration
  3. washwashed with 75 mL of water
  4. customdried at 60° C. under vacuum

来源与证据

ORD记录
ord-6cdb42c88e1c4050ae28ae6ce211a291
来源数据集
uspto-grants-1998_03
专利号
US05726319

关联笔记

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