3,4-二氢-2H-吡喃 → Diethyl 5-(tetrahydropyran-2-yloxy)pentylphosphonate

HRID 2013

反应方程式

HRID 2013 反应方程式
[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][P:7](=[O:14])([O:11][CH2:12][CH3:13])[O:8][CH2:9][CH3:10].[O:15]1[CH:20]=[CH:19][CH2:18][CH2:17][CH2:16]1.C1(C)C=CC(S([O-])(=O)=O)=CC=1.[NH+]1C=CC=CC=1>ClCCl>[O:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH:16]1[O:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][P:7](=[O:14])([O:8][CH2:9][CH3:10])[O:11][CH2:12][CH3:13]

参与物

5

反应物 3

HCID 80803,4-二氢-2H-吡喃HCID 4661024-甲基苯磺酸吡啶HCID 10680635Diethyl 5-hydroxypentylphosphonate

产物 1

HCID 19689209Diethyl 5-(tetrahydropyran-2-yloxy)pentylphosphonate

试剂、催化剂与溶剂 1

HCID 6344二氯甲烷溶剂

实验过程

A solution of 66.9 g (0.298 mol) of diethyl 5-hydroxypentylphosphonate, 32.6 g (0.38 mol) of 3,4-dihydropyran and 1 g (0.004 mol) of pyridinium toluene-4-sulfonate in 800 ml of dichloromethane was heated under reflux for 16 hours. The solution was washed with water and saturated sodium hydrogen carbonate solution, dried over sodium sulfate and distilled in a bulb tube.

后处理

  1. temperatureunder reflux for 16 hours
  2. washThe solution was washed with water and saturated sodium hydrogen carbonate solution
  3. dry with materialdried over sodium sulfate
  4. distillationdistilled in a bulb tube

来源与证据

ORD记录
ord-1e24e4dd0b0641159e1602ba6f4a336e
来源数据集
uspto-grants-1998_03
专利号
US05728686

关联笔记

加载中…