乙酰胺 → Acetamidoglycolic acid

HRID 20187

反应方程式

HRID 20187 反应方程式
[C:1]([NH2:4])(=[O:3])[CH3:2].[C:5]([OH:9])(=[O:8])[CH:6]=[O:7]>CC(C)=O>[C:1]([NH:4][CH:6]([OH:7])[C:5]([OH:9])=[O:8])(=[O:3])[CH3:2]

参与物

4

反应物 2

HCID 178乙酰胺HCID 760乙醛酸

产物 1

HCID 14212846Acetamidoglycolic acid

试剂、催化剂与溶剂 1

HCID 180丙酮溶剂

实验过程

A mixture of commercially available acetamide 34 and glyoxylic acid 41 was heated at reflux in acetone to give pure N-acetyl-2-hydroxyglycine 42 as a viscous yellow oil in quantitative yield. The 1H n.m.r. spectrum supported formation of the α-hydroxyglycine derivative 42 with the appearance of a methine (H2) doublet and broad amide (NH) doublet at δ 5.39 and δ 8.65 respectively. Spectroscopic data were in agreement with those reported in the literature.195

后处理

  1. temperaturewas heated

来源与证据

ORD记录
ord-e76f8a57f7894eaca8797727c758d1d0
来源数据集
uspto-grants-2010_06
专利号
US07745573B2

关联笔记

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