乙醛酸 → Α-羟基马尿酸

HRID 20188

反应方程式

HRID 20188 反应方程式
[C:1]([NH2:9])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:10]([OH:14])(=[O:13])[CH:11]=[O:12]>CC(C)=O>[C:1]([NH:9][CH:11]([OH:12])[C:10]([OH:14])=[O:13])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参与物

4

反应物 2

HCID 760乙醛酸HCID 2331苯甲酰胺

产物 1

HCID 450272Α-羟基马尿酸

试剂、催化剂与溶剂 1

HCID 180丙酮溶剂

实验过程

A mixture of commercially available benzamide 35 and glyoxylic acid 41 was heated at reflux in acetone to give pure N-benzoyl-2-hydroxyglycine 65 as a colourless solid in quantitative yield (Scheme 4.12). The 1H n.m.r. spectrum supported formation of the ox-hydroxyglycine derivative 65 with the appearance of a methine (H2) doublet and broad amide (NH) doublet at δ 5.60 and δ 9.26 respectively. Spectroscopic data were in agreement with those reported in the literature.209

后处理

  1. temperaturewas heated

来源与证据

ORD记录
ord-9b741076ad9544a8b379ce92eb9f70b0
来源数据集
uspto-grants-2010_06
专利号
US07745573B2

关联笔记

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