2-氯-2-苯基苯乙酮 → Thiazole, triphenyl-

HRID 2049272

反应方程式

HRID 2049272 反应方程式
[C:1]([NH2:9])(=[S:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:10]1([C:16]([CH:18](Cl)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=O)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>C(O)(C)C>[C:10]1([C:16]2[S:8][C:1]([C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[N:9][C:18]=2[C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1

参与物

4

反应物 2

HCID 953432-氯-2-苯基苯乙酮HCID 683563硫代苯甲酰胺

产物 1

HCID 1712256Thiazole, triphenyl-

试剂、催化剂与溶剂 1

HCID 3776异丙醇溶剂

实验过程

Thiobenzamide (13.7 g, 0.10 mole) and desyl chloride (23.1 g, 0.10 mole) are heated under reflux in isopropyl alcohol (100 ml) for three hours. When the reaction mixture is cooled, the white solid precipitate formed is filtered off, washed twice with isopropyl alcohol, and dried. The yield of triphenylthiazole, m.p. 84°-85.5° C., is 21.5 g or 69%.

后处理

  1. temperatureWhen the reaction mixture is cooled
  2. customthe white solid precipitate formed
  3. filtrationis filtered off
  4. washwashed twice with isopropyl alcohol
  5. customdried

来源与证据

ORD记录
ord-3912ad2349f94687be5fa180fdf6869a
来源数据集
uspto-grants-1980_04
专利号
US04197306

关联笔记

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