1-[2-(2-羟基乙氧基)乙基]哌嗪 → 4-Chloro-7-{1-(tert-butoxycarbonyl)-5-[4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-ylmethyl]indol-2-yl}isoindolinone

HRID 21057

反应方程式

HRID 21057 反应方程式
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]([C:22]([O:24][C:25]([CH3:28])([CH3:27])[CH3:26])=[O:23])[C:13]3[C:18]([CH:19]=2)=[CH:17][C:16]([CH:20]=O)=[CH:15][CH:14]=3)=[C:7]2[C:3]=1[CH2:4][NH:5][C:6]2=[O:29].[OH:30][CH2:31][CH2:32][O:33][CH2:34][CH2:35][N:36]1[CH2:41][CH2:40][NH:39][CH2:38][CH2:37]1.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>ClCCl>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([C:11]2[N:12]([C:22]([O:24][C:25]([CH3:27])([CH3:26])[CH3:28])=[O:23])[C:13]3[C:18]([CH:19]=2)=[CH:17][C:16]([CH2:20][N:39]2[CH2:40][CH2:41][N:36]([CH2:35][CH2:34][O:33][CH2:32][CH2:31][OH:30])[CH2:37][CH2:38]2)=[CH:15][CH:14]=3)=[C:7]2[C:3]=1[CH2:4][NH:5][C:6]2=[O:29]

参与物

5

反应物 3

HCID 1394361-[2-(2-羟基乙氧基)乙基]哌嗪HCID 5049666三乙酰氧基硼氢化钠HCID 866282274-Chloro-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone

产物 1

HCID 684925034-Chloro-7-{1-(tert-butoxycarbonyl)-5-[4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-ylmethyl]indol-2-yl}isoindolinone

试剂、催化剂与溶剂 1

HCID 6344二氯甲烷溶剂

实验过程

In a similar manner to Step 1 of Example 56, 4-chloro-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone (20.0 mg, 0.0487 mmol) was dissolved in dichloromethane (0.5 mL). The solution was treated with 1-[2-(2-hydroxyethoxy)ethyl]piperazine (35 mg, 0.20 mmol) and sodium triacetoxyborohydride (32 mg, 0.15 mmol) to obtain 4-chloro-7-{1-(tert-butoxycarbonyl)-5-[4-(2-(2-hydroxyethoxy)ethyl)piperazin-1-ylmethyl]indol-2-yl}isoindolinone.

来源与证据

ORD记录
ord-a10796da6bff45cfa8a6359052c5bf45
来源数据集
uspto-grants-2010_06
专利号
US07745641B2

关联笔记

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