氯化亚砜 → (4-(氯甲基)吡啶-2-基)氨基甲酸叔丁酯

HRID 2205337

反应方程式

HRID 2205337 反应方程式
O[CH2:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([NH:9][C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH:4]=1.O=S(Cl)[Cl:19]>C(Cl)Cl>[Cl:19][CH2:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([NH:9][C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH:4]=1

参与物

4

反应物 2

HCID 24386氯化亚砜HCID 231510012-(BOC-氨基)-4-羟甲基吡啶

产物 1

HCID 21068467(4-(氯甲基)吡啶-2-基)氨基甲酸叔丁酯

试剂、催化剂与溶剂 1

HCID 6344二氯甲烷溶剂

实验过程

tert-butyl (4-(hydroxymethyl)pyridin-2-yl)carbamate (600 mg, 2.679 mmol) was first treated with SOCl2 (3 ml) in CH2Cl2 (5 ml) at rt for 2 hrs. The solvent was removed to get a crude tert-butyl (4-(chloromethyl)pyridin-2-yl)carbamate. Then following General Procedure A, the title compound (667 mg, 68%) was prepared from 2-amino-4-chlorobenzenethiol (641 mg, 4.019 mmol), K2CO3 (1.8 g, 13.39 mmol) in DMF (20 ml).

后处理

  1. customThe solvent was removed

来源与证据

ORD记录
ord-04c0f152d84c44d184a10f73907e4b9e
来源数据集
uspto-grants-2016_06
专利号
US09371278B2

关联笔记

加载中…