2-溴月桂酸 → 2-chlorododecanoic Acid

HRID 2210836

反应方程式

HRID 2210836 反应方程式
Br[CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[C:3]([OH:5])=[O:4].[Cl-:16].[Ca+2].[Cl-]>C(#N)C.[Cl-].C([N+](CC)(CC)CC)C>[Cl:16][CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[C:3]([OH:5])=[O:4]

参与物

5

反应物 2

HCID 669802-溴月桂酸HCID 5284359氯化钙

产物 1

HCID 43873702-chlorododecanoic Acid

试剂、催化剂与溶剂 2

HCID 5946四乙基氯化铵催化剂HCID 6342乙腈溶剂

实验过程

To 2-bromododecanoic acid (1 g), after having been dissolved in acetonitrile (50 ml ), were added calcium chloride (2 g) and tetraethylammonium chloride (1 g), and the mixture was heated under reflux for 4 hours. The reaction mixture was filtered, concentrated and distributed into ethyl acetate and water, and the ethyl acetate layer was dried over anhydrous sodium sulfate and concentrated to give 2-chlorododecanoic acid.

后处理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 4 hours
  3. filtrationThe reaction mixture was filtered
  4. concentrationconcentrated
  5. dry with materialthe ethyl acetate layer was dried over anhydrous sodium sulfate
  6. concentrationconcentrated

来源与证据

ORD记录
ord-1166962bf9cc4f59a854ba6f25ac7e21
来源数据集
uspto-grants-1995_10
专利号
US05461036

关联笔记

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