海萝胶 → 3-Amino-4-fluorobutanoic acid hcl

HRID 223320

反应方程式

HRID 223320 反应方程式
[F:1][CH2:2][CH:3]([NH:8]C(OC(C)(C)C)=O)[CH2:4][C:5]([OH:7])=[O:6].[ClH:16]>CCOCC>[ClH:16].[F:1][CH2:2][CH:3]([NH2:8])[CH2:4][C:5]([OH:7])=[O:6]

参与物

4

反应物 2

HCID 313海萝胶HCID 205083403-Boc-amino-4-fluorobutanoic acid

产物 1

HCID 860072723-Amino-4-fluorobutanoic acid hcl收率 68%

试剂、催化剂与溶剂 1

HCID 3283乙醚溶剂

实验过程

4-Fluoro-3-tert-butoxycarbonylamino-1-butanoic acid (545 mg, 2.46 mmoles) is dissolved in dry ether (20 ml) saturated with hydrogen chloride gas. After a few minutes, the solution becomes turbid and white crystals start to precipitate. Recrystallization from ethanol by addition of diethylether affords 4-fluoro-3-amino-1-butanoic acid hydrochloride (265 mg, 68%), m.p. 152°-153° C. (dec).

后处理

  1. waitAfter a few minutes
  2. customto precipitate
  3. customRecrystallization from ethanol
  4. additionby addition of diethylether

来源与证据

ORD记录
ord-4edc7ec33ded4ecbb062a1d2ef3af030
来源数据集
uspto-grants-1982_10
专利号
US04353828

关联笔记

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