N,N-二甲基甲酰胺 → 5-乙基-2-糠醛

HRID 235108

反应方程式

HRID 235108 反应方程式
CN([CH:4]=[O:5])C.O=P(Cl)(Cl)Cl.[CH2:11]([C:13]1[O:14][CH:15]=[CH:16][CH:17]=1)[CH3:12]>>[CH2:11]([C:13]1[O:14][C:15]([CH:4]=[O:5])=[CH:16][CH:17]=1)[CH3:12]

参与物

4

反应物 3

HCID 6228N,N-二甲基甲酰胺HCID 185542-乙基呋喃HCID 24813三氯氧磷

产物 1

HCID 899895-乙基-2-糠醛收率 68.9%

反应条件

温度
0 °C

实验过程

A sample of DMF (9.3 mL, 120 mmol) was cooled to 0° C. and POCl3 (3.37 g, 22 mmol) was added, the mixture was stirred for 1 hour at 0° C., then 2-ethyl furan (1.92 g, 20 mmol) was added. The reaction was quenched by pouring onto ice, and the mixture was stirred for 18 hours. The mixture was extracted with hexane, which was dried over MgSO4 and concentrated to give 1.71 g of the title compound (used without further purification).

后处理

  1. customThe reaction was quenched
  2. additionby pouring onto ice
  3. stirringthe mixture was stirred for 18 hours
  4. extractionThe mixture was extracted with hexane, which
  5. dry with materialwas dried over MgSO4
  6. concentrationconcentrated

来源与证据

ORD记录
ord-8d178fb4c5434ea987c1f70c41398c35
来源数据集
uspto-grants-1997_01
专利号
US05597832

关联笔记

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