参与物
| 角色 | 名称 | HCID | 投料 |
|---|
| 反应物 | 三苯基膦 | HCID 11776 | — |
| 反应物 | 对羟基苯丙酸甲酯 | HCID 79706 | — |
| 反应物 | (3-(Phenylamino)phenyl)methanol | HCID 12882229 | — |
| 反应物 | Diethylazodicarboxylate toluene | HCID 66777355 | — |
| 溶剂 | 四氢呋喃 | HCID 8028 | — |
| 产物 | Methyl 3-[4-[(3-anilinobenzyl)oxy]phenyl]propanoate | HCID 57541953 | 50% |
反应步骤
To a mixture of (3-anilinophenyl)methanol (1.12 g, 5.62 mmol), methyl 3-(4-hydroxyphenyl)propanoate (1.22 g, 6.75 mmol), triphenylphosphine (1.92 g, 7.31 mmol) and tetrahydrofuran (20 mL) was added diethyl azodicarboxylate toluene solution (40%, 3.32 mL) with stirring at 0° C. and the mixture was stirred at room temperature for 14 hrs. The reaction mixture was concentrated, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate=10/1-2/1) to give the title compound (1.01 g, yield 50%) as beige crystals.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 专利号 | US07960369B2 |
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| 来源数据集 | uspto-grants-2011_06 |
|---|
| ORD ID | ord-91d14e223e39464da398c116911a8c17 |
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| 来源说明 | uspto-grants-2011_06 |
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