一甲胺 → N-(2-Methoxyphenyl)-4-(methylamino)methylbenzamide

HRID 2455

反应方程式

HRID 2455 反应方程式
Cl[CH2:2][C:3]1[CH:19]=[CH:18][C:6]([C:7]([NH:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16][CH3:17])=[O:8])=[CH:5][CH:4]=1.[CH3:20][NH2:21]>O1CCOCC1>[CH3:17][O:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[NH:9][C:7](=[O:8])[C:6]1[CH:18]=[CH:19][C:3]([CH2:2][NH:21][CH3:20])=[CH:4][CH:5]=1

参与物

4

反应物 2

HCID 6329一甲胺HCID 196899684-Chloromethyl-N-(2-methoxyphenyl)benzamide

产物 1

HCID 19690083N-(2-Methoxyphenyl)-4-(methylamino)methylbenzamide收率 100%

试剂、催化剂与溶剂 1

HCID 312751,4-二氧六环溶剂2 次

实验过程

4-Chloromethyl-N-(2-methoxyphenyl)benzamide (400 mg, 1.45 mmol) was dissolved in dioxane (4 ml) and then mixed with 50% methylamine aqueous solution (4 ml) at room temperature. After 1 hour of stirring at the same temperature, dioxane was removed by evaporation, and the resulting residue was diluted with methylene chloride (10 ml). After drying on anhydrous sodium carbonate, the solvent was removed by evaporation to obtain 500 mg (100%) of the title compound in the form of colorless oil.

后处理

  1. customwas removed by evaporation
  2. additionthe resulting residue was diluted with methylene chloride (10 ml)
  3. dry with materialAfter drying on anhydrous sodium carbonate
  4. customthe solvent was removed by evaporation

来源与证据

ORD记录
ord-1e483b3adf244fe28b89df6ce80d81bc
来源数据集
uspto-grants-1998_03
专利号
US05728835

关联笔记

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