2,5-二甲氧基四氢呋喃 → 2-Chloro-4-(1-pyrrolyl)benzoic acid methyl ester

HRID 24717

反应方程式

HRID 24717 反应方程式
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([NH2:10])=[CH:6][C:5]=1[Cl:11].CO[CH:15]1[CH2:19][CH2:18][CH:17](OC)O1>CC(O)=O.O>[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH:15]=[CH:19][CH:18]=[CH:17]2)=[CH:6][C:5]=1[Cl:11]

参与物

5

反应物 2

HCID 790982,5-二甲氧基四氢呋喃HCID 118391974-氨基-2-氯苯甲酸甲酯

产物 1

HCID 47637352-Chloro-4-(1-pyrrolyl)benzoic acid methyl ester

试剂、催化剂与溶剂 2

HCID 176醋酸溶剂HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂

实验过程

A mixture of 4-amino-2-chlorobenzoic acid methyl ester (0.46 g) and 2,5-dimethoxytetrahydrofuran (0.33 mL) in AcOH (16 mL) was heated under reflux for 2 h. The mixture was cooled to room temperature, diluted with water and extracted with EtOAc. The extract was washed with satd. NaHCO3 and brine, dried (MgSO4), filtered and evaporated. The residue was purified by column chromatography (silica gel; eluent: hexane/EtOAc 5/1) to yield 0.48 g of 2-chloro-4-(1-pyrrolyl)benzoic acid methyl ester. ESMS: m/z 236 (MH+).

后处理

  1. temperaturewas heated
  2. temperatureunder reflux for 2 h
  3. extractionextracted with EtOAc
  4. washThe extract was washed with satd
  5. dry with materialNaHCO3 and brine, dried (MgSO4)
  6. filtrationfiltered
  7. customevaporated
  8. customThe residue was purified by column chromatography (silica gel; eluent: hexane/EtOAc 5/1)

来源与证据

ORD记录
ord-7d9c216325c049cd98f689b70dd37e81
来源数据集
uspto-grants-2005_02
专利号
US06855843B2

关联笔记

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