四氢噻吩 → Phenacyltetrahydrothiophenium bromide

HRID 24964

反应方程式

HRID 24964 反应方程式
[S:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:6]([Br:15])[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8]>C(#N)C>[Br-:15].[CH2:6]([S+:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8]

参与物

4

反应物 2

HCID 1127四氢噻吩HCID 62592-溴苯乙酮

产物 1

HCID 11346720Phenacyltetrahydrothiophenium bromide收率 94.9%

试剂、催化剂与溶剂 1

HCID 6342乙腈溶剂2 次

实验过程

Tetrahydrothiophene (53.2 g) was dissolved in 400 ml of acetonitrile, and thereto was slowly added a solution obtained by dissolving 100 g of phenacyl bromide in 300 ml of acetonitrile, and the solution was stirred at room temperature for 3 hours, thereby a powder was precipitated. The reaction solution was poured into 1,500 ml of ethyl acetate, and the powder was filtered out and dried, thus 137 g of phenacyltetrahydrothiophenium bromide was obtained.

后处理

  1. additionwas slowly added a solution
  2. customobtained
  3. customa powder was precipitated
  4. additionThe reaction solution was poured into 1,500 ml of ethyl acetate
  5. filtrationthe powder was filtered out
  6. customdried

来源与证据

ORD记录
ord-92317603e81c4877acde22e58de207d2
来源数据集
uspto-grants-2005_02
专利号
US06858370B2

关联笔记

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