四氢噻吩 → 1-(3,3-二甲基-2-氧代丁基)四氢-1H-噻吩-1-溴化鎓

HRID 24968

反应方程式

HRID 24968 反应方程式
[S:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[Br:6][CH2:7][C:8](=[O:13])[C:9]([CH3:12])([CH3:11])[CH3:10]>C(#N)C>[Br-:6].[O:13]=[C:8]([C:9]([CH3:12])([CH3:11])[CH3:10])[CH2:7][S+:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1

参与物

4

反应物 2

HCID 1127四氢噻吩HCID 216421-溴频哪酮

产物 1

HCID 225645781-(3,3-二甲基-2-氧代丁基)四氢-1H-噻吩-1-溴化鎓收率 80.4%

试剂、催化剂与溶剂 1

HCID 6342乙腈溶剂

实验过程

Tetrahydrothiophene (11.8 g) was dissolved in 100 ml of acetonitrile, and 20 g of 1-bromo-3,3-dimethyl-2-butanone was slowly added to the above solution. The reaction solution was stirred at room temperature for two days, thereby a powder was precipitated. After adding 100 ml of ethyl acetate to the reaction solution, the powder was filtered out, washed with ethyl acetate and dried, thereby 24 g of 2-oxo-3,3-dimethylbutyltetrahydrothiophenium bromide was obtained.

后处理

  1. customa powder was precipitated
  2. additionAfter adding 100 ml of ethyl acetate to the reaction solution
  3. filtrationthe powder was filtered out
  4. washwashed with ethyl acetate
  5. customdried

来源与证据

ORD记录
ord-11e4aee2f6d84e11a6513bca5d39247a
来源数据集
uspto-grants-2005_02
专利号
US06858370B2

关联笔记

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