醋酸 → 2-溴-4'-碘苯乙酮

HRID 251762

反应方程式

HRID 251762 反应方程式
[I:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][CH:3]=1.C(O)(=O)C.[Br:15]Br>O>[Br:15][CH2:9][C:8]([C:5]1[CH:6]=[CH:7][C:2]([I:1])=[CH:3][CH:4]=1)=[O:10]

参与物

5

反应物 3

HCID 176醋酸HCID 24408Government regulation2 次HCID 728694-碘代苯乙酮

产物 1

HCID 2565722-溴-4'-碘苯乙酮收率 102.6%

试剂、催化剂与溶剂 1

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂

反应条件

温度
15 °C

实验过程

Dissolving 20 g (81 mmol) of 4′-iodo acetophenone into 200 milliliter of acetic acid, and adding 12.8 g (81 mmol) of bromine while cooling with ice, stirred at the temperature of 15° C. for 3 hours. After the color of bromine disappeared, adding water and separating the precipitated solids by filtration, thereby obtained 27 g of crude 2-bromo-4′-iodo acetophenone.

后处理

  1. temperaturewhile cooling with ice
  2. customseparating the precipitated solids
  3. filtrationby filtration

来源与证据

ORD记录
ord-4f186ab3782a4e79825b256306f12e77
来源数据集
uspto-grants-2011_01
专利号
US07867629B2

关联笔记

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