2-甲基磺酰苯磺酰氯 → N-(3-cyano-1H-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide

HRID 25360

反应方程式

HRID 25360 反应方程式
[C:1]([C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([NH2:12])[CH:10]=2)[NH:5][N:4]=1)#[N:2].[CH3:13][S:14]([C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[S:23](Cl)(=[O:25])=[O:24])(=[O:16])=[O:15]>N1C=CC=CC=1>[C:1]([C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([NH:12][S:23]([C:18]3[CH:19]=[CH:20][CH:21]=[CH:22][C:17]=3[S:14]([CH3:13])(=[O:16])=[O:15])(=[O:25])=[O:24])[CH:10]=2)[NH:5][N:4]=1)#[N:2]

参与物

4

反应物 2

HCID 27351782-甲基磺酰苯磺酰氯HCID 225673035-氨基-1H-吲唑-3-甲腈

产物 1

HCID 10045063N-(3-cyano-1H-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide收率 11.5%

试剂、催化剂与溶剂 1

HCID 1049吡啶溶剂

实验过程

N-(3-Cyano-1H-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide can be obtained as described in Example 2 from 0.55 g of 3-cyano-5-amino-1H-indazole, 10 ml of pyridine and 0.88 g of 2-methylsulfonylbenzenesulfonyl chloride. 0.15 g of N-(3-cyano-1H-indazol-5-yl)-2-methylsulfonylbenzenesulfonamide is thus obtained in the form of a yellow powder melting at 272° C. (analysis C15H12N4O4S2.0.85H2O, % calculated C, 47.87; H, 3.21; N, 14.88; S, 17.04. % found C, 47.88; H, 3.01; N, 14.75; S, 17.45).

来源与证据

ORD记录
ord-f83a3feddd8547ec88d94ae942a358e4
来源数据集
uspto-grants-2005_02
专利号
US06858638B2

关联笔记

加载中…