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3,4-二氯苯甲基磺酰氯 → 3,4-dichloro-N-(1H-indazol-5-yl)benzenesulfonamide
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 3,4-二氯苯甲基磺酰氯 | HCID 7383 | — |
| 反应物 | 5-氨基吲唑 | HCID 88012 | — |
| 溶剂 | 吡啶 | HCID 1049 | — |
| 产物 | 3,4-dichloro-N-(1H-indazol-5-yl)benzenesulfonamide | HCID 10065942 | 21.4% |
反应步骤
3,4-Dichloro-N-(1H-indazol-5-yl)benzenesulfonamide can be obtained as described in Example 2 from 1 g of 5-amino-1H-indazole, 20 ml of pyridine and 1.84 g of 3,4-dichlorobenzenesulfonyl chloride. 0.55 g of 3,4-dichloro-N-(1H-indazol-5-yl)benzenesulfonamide is thus obtained in the form of a green solid melting at 209° C. (analysis C13H9Cl2N3O2S % calculated C, 45.63; H, 2.65; Cl, 20.72; N, 12.28; O, 9.35; S, 9.37. % found C, 45.87; H, 2.72; Cl, 21.10; N, 12.27; S, 9.21).
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US06858638B2 |
| 来源数据集 | uspto-grants-2005_02 |
| ORD ID | ord-af023ee423194ec1abb7f225a7034e30 |
| 来源说明 | uspto-grants-2005_02 |