乙酸乙酯 → 4-{3-[5-(5,6-Difluoro-1H-indol-2-yl)-2-methoxy-phenyl]-thioureido}-benzoic acid

HRID 25493

反应方程式

HRID 25493 反应方程式
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[F:11])[NH:7][C:6]([C:12]1[CH:13]=[CH:14][C:15]([O:19][CH3:20])=[C:16]([NH2:18])[CH:17]=1)=[CH:5]2.[C:21]([C:24]1[CH:29]=[CH:28][C:27]([N:30]=[C:31]=[S:32])=[CH:26][CH:25]=1)([OH:23])=[O:22].C(OCC)(=O)C>O1CCCC1>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[F:11])[NH:7][C:6]([C:12]1[CH:13]=[CH:14][C:15]([O:19][CH3:20])=[C:16]([NH:18][C:31](=[S:32])[NH:30][C:27]3[CH:26]=[CH:25][C:24]([C:21]([OH:23])=[O:22])=[CH:29][CH:28]=3)[CH:17]=1)=[CH:5]2

参与物

5

反应物 3

HCID 8857乙酸乙酯HCID 2429464-羧基苯基异硫氰酸酯2 次HCID 99434395-(5,6-difluoro1H-indol-2-yl)-2-methoxy-phenylamine2 次

产物 1

HCID 101150264-{3-[5-(5,6-Difluoro-1H-indol-2-yl)-2-methoxy-phenyl]-thioureido}-benzoic acid

试剂、催化剂与溶剂 1

HCID 8028四氢呋喃溶剂

反应条件

温度
50 °C

实验过程

The product from Example 3, 5-(5,6-difluoro-1H-indol-2-yl)-2-methoxy-phenylamine, (0.274 g, 1.0 mmol) was mixed with 4-carboxyphenyl isothiocyanate (0.183 g, 1.0 mmol) in tetrahydrofuran (10 mL) and was heated briefly to 50° C. and then allowed to stand overnight at room temperature. The tetrahydrofuran was boiled off on the rotary evaporator (no vacuum) to give a solid. Ethyl acetate (5 mL) was added, and the mixture was allowed to stand overnight at room temperature. The insoluble material was collected by filtration and was a mixture. All material from the reaction mixture was taken up in tetrahydrofuran/ethyl acetate and more 4-carboxyphenyl isothiocyanate (0.020 g, 0.11 mmol) was added and the solvent was boiled off on the rotary evaporator. Ethyl acetate was added to the solid and the mixture allowed to stand overnight at room temperature. The insoluble material was collected by filtration (0.191 g), mp 201-203° C.

后处理

  1. customThe tetrahydrofuran was boiled off on the rotary evaporator (no vacuum)
  2. customto give a solid
  3. waitto stand overnight at room temperature
  4. filtrationThe insoluble material was collected by filtration
  5. customthe solvent was boiled off on the rotary evaporator
  6. additionEthyl acetate was added to the solid
  7. waitto stand overnight at room temperature
  8. filtrationThe insoluble material was collected by filtration (0.191 g), mp 201-203° C.

来源与证据

ORD记录
ord-0bb20bfbad2d47d092416d18cf09c6c3
来源数据集
uspto-grants-2005_02
专利号
US06858739B2

关联笔记

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