alpha-Ethyl-alpha-methyl-dihydrocinnamic acid → 2-Ethyl-2-methyl-1-indanone

HRID 261528

反应方程式

HRID 261528 反应方程式
[CH2:1]([C:3]([CH3:14])([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:4]([OH:6])=O)[CH3:2]>O>[CH2:1]([C:3]1([CH3:14])[CH2:7][C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:4]1=[O:6])[CH3:2]

参与物

3

反应物 1

HCID 20394459alpha-Ethyl-alpha-methyl-dihydrocinnamic acid

产物 1

HCID 146860942-Ethyl-2-methyl-1-indanone

试剂、催化剂与溶剂 1

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂

实验过程

69 g of α-ethyl-α-methyl-dihydrocinnamic acid are added dropwise at 150°, within 5 minutes, to 700 g of polyphosphoric acid, while stirring. The reaction mixture is stirred at 160° for a further 10 minutes, is cooled to 100° and 100 cc of water are added dropwise. The reaction mixture is then poured on ice, extracted with ether, the ether extract is washed with water and dried over sodium sulphate. The 2-ethyl-2-methyl-1-indanone, obtained after evaporating the solvent, is purified by distillation. B.P. 137°-140° at 20 mm of Hg.

后处理

  1. stirringThe reaction mixture is stirred at 160° for a further 10 minutes
  2. temperatureis cooled to 100°
  3. additionThe reaction mixture is then poured on ice
  4. extractionextracted with ether
  5. extractionthe ether extract
  6. washis washed with water
  7. dry with materialdried over sodium sulphate

来源与证据

ORD记录
ord-d280e6f49a1b4e39adc6e5d503e9626b
来源数据集
uspto-grants-1979_08
专利号
US04166131

关联笔记

加载中…