2-氯-2-苯基苯乙酮 → 2-(3,4-Methylenedioxyphenyl)-4,5-diphenylthiazole

HRID 262128

反应方程式

HRID 262128 反应方程式
[C:1]([NH2:12])(=[S:11])[C:2]1[CH:10]=[CH:9][C:8]2[O:7][CH2:6][O:5][C:4]=2[CH:3]=1.[C:13]1([C:19]([CH:21](Cl)[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=O)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>C(O)C>[CH2:6]1[O:7][C:8]2[CH:9]=[CH:10][C:2]([C:1]3[S:11][C:19]([C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)=[C:21]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[N:12]=3)=[CH:3][C:4]=2[O:5]1

参与物

4

反应物 2

HCID 953432-氯-2-苯基苯乙酮HCID 27761263,4-(亚甲基二氧基)硫代甲酰氨

产物 1

HCID 203449832-(3,4-Methylenedioxyphenyl)-4,5-diphenylthiazole收率 67.1%

试剂、催化剂与溶剂 1

HCID 702乙醇溶剂

实验过程

Thiopiperonylamide (18.1g, 0.10 mole) and desyl chloride (23.1g, 0.10 mole) are heated under reflux in 95% ethanol (100 ml) for two hours. An oil precipitates which solidifies when the reaction mixture is cooled. The solid is collected and recrystallized from ethanolethyl acetate to give 24.0g (67% yield) of 2-(3,4-methylenedioxyphenyl)-4,5-diphenylthiazole, m.p. 121°-124° C. Thiopiperonylamide is also prepared from the corresponding nitrile by the method of Fairfull et al., J. Chem. Soc. 1952, 742.

后处理

  1. customAn oil precipitates which
  2. temperatureis cooled
  3. customThe solid is collected
  4. customrecrystallized from ethanolethyl acetate

来源与证据

ORD记录
ord-e5b0204e8488451689e553449c72c4ac
来源数据集
uspto-grants-1979_05
专利号
US04153703

关联笔记

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