乙醚 → 9b-Allyl-8-methoxy-3-methyl-5,9b-dihydrobenz[e]indoline

HRID 26401

反应方程式

HRID 26401 反应方程式
[CH2:1]1[C:9]2[C:8]3[CH:10]=[CH:11][CH:12]=[CH:13][C:7]=3[CH:6]=[CH:5][C:4]=2[NH:3][CH2:2]1.[C:14]1(C([O-])=C([N+]([O-])=O)C=[C:19]([N+]([O-])=O)[CH:18]=1)[N+]([O-])=O.C1([C:44]([OH:45])=C([N+]([O-])=O)C=C([N+]([O-])=O)C=1)[N+]([O-])=O.[OH-].[Li+].[CH3:48]COCC>C(O)C>[CH2:19]([C:9]12[C:8]3[CH:10]=[C:11]([O:45][CH3:44])[CH:12]=[CH:13][C:7]=3[CH2:6][CH:5]=[C:4]1[N:3]([CH3:48])[CH2:2][CH2:1]2)[CH:18]=[CH2:14]

参与物

7

反应物 5

HCID 3283乙醚HCID 3939氢氧化锂HCID 6954苦味酸HCID 4432340Picrate3 次HCID 111479652,3-二氢-1H-苯并[E]吲哚

产物 1

HCID 233307809b-Allyl-8-methoxy-3-methyl-5,9b-dihydrobenz[e]indoline

试剂、催化剂与溶剂 1

HCID 702乙醇溶剂

实验过程

The benz[e]indoline IIa regenerated from the picrate XIVd (X=picric acid) as follows: A mixture of finely powder picrate (10 mmol), 1 N aqueous lithium hydroxide (50 ml), ethanol (20 ml) and ether (100 ml) in a separatory funnel was shaken until all the picrate had dissolved. The ether phase was washed with water and, after drying, was evaporated to dryness to give the free base IIa quantitatively.

后处理

  1. dissolutionhad dissolved
  2. washThe ether phase was washed with water
  3. customafter drying
  4. customwas evaporated to dryness
  5. customto give the free base IIa quantitatively

来源与证据

ORD记录
ord-16a17a0b36e14ed6b91cdc45dfc700a2
来源数据集
uspto-grants-1979_04
专利号
US04150032

关联笔记

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