二乙烯三胺 → 2,2,2-trifluoro-N-[2-[2-[(2,2,2-trifluoroacetyl)amino]ethylamino]ethyl]acetamide

HRID 2671

反应方程式

HRID 2671 反应方程式
C(O[C:4](=[O:9])[C:5]([F:8])([F:7])[F:6])C.[NH2:10][CH2:11][CH2:12][NH:13][CH2:14][CH2:15][NH2:16]>O1CCCC1>[F:6][C:5]([F:8])([F:7])[C:4]([NH:10][CH2:11][CH2:12][NH:13][CH2:14][CH2:15][NH:16][C:4](=[O:9])[C:5]([F:6])([F:7])[F:8])=[O:9]

参与物

4

反应物 2

HCID 8111二乙烯三胺HCID 9794三氟乙酸乙酯

产物 1

HCID 3887782,2,2-trifluoro-N-[2-[2-[(2,2,2-trifluoroacetyl)amino]ethylamino]ethyl]acetamide

试剂、催化剂与溶剂 1

HCID 8028四氢呋喃溶剂

实验过程

113.3 g (790 mmol) of trifluoroacetic acid ethyl ester is instilled in a solution of 41.14 g (390 mmol) of 1,4,7-triazaheptane in 350 ml of tetrahydrofuran at 0° C. and under nitrogen. It is allowed to stir overnight at room temperature, concentrated by evaporation in a vacuum. The remaining oil is crystallized from hexane.

后处理

  1. concentrationconcentrated by evaporation in a vacuum
  2. customThe remaining oil is crystallized from hexane

来源与证据

ORD记录
ord-5c5e1fcc0a6a453590b1c97dc343fa23
来源数据集
uspto-grants-1998_03
专利号
US05730956

关联笔记

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