三苯基膦 → 3-Methyl-4-methoxybenzyl triphenylphosphonium chloride

HRID 270156

反应方程式

HRID 270156 反应方程式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][Cl:10])=[CH:5][C:4]=1[CH3:11].[C:12]1([P:18]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C1(C)C=CC=CC=1>[Cl-:10].[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([CH2:9][P+:18]([C:19]2[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=2)([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)=[CH:5][C:4]=1[CH3:11]

参与物

4

反应物 2

HCID 11776三苯基膦HCID 1437424-甲氧基-3-甲基苯甲基氯

产物 1

HCID 461800353-Methyl-4-methoxybenzyl triphenylphosphonium chloride收率 71%

试剂、催化剂与溶剂 1

HCID 1140甲苯溶剂

实验过程

To a 250ml round-bottom flask equipped with a magnetic stir-bar and N2inlet was added 4-(Chloromethyl)-2-methylphenyl methyl ether (2.59g, 15.18mmoles, 1eq), dry toluene (50ml, 0.3M) and triphenylphosphine (3.98g, 15.18mmoles, 1eq). The reaction mixture was refluxed overnight. After cooling to room temperature the solvent was removed in vacuo, the residue washed with hexanes and the solid/liquid mixture was filtered to yield 4.48g (71%) of solid product.

后处理

  1. customTo a 250ml round-bottom flask equipped with a magnetic stir-bar
  2. temperatureThe reaction mixture was refluxed overnight
  3. customwas removed in vacuo
  4. washthe residue washed with hexanes
  5. filtrationthe solid/liquid mixture was filtered

来源与证据

ORD记录
ord-a8fd80fb3ecd46b39c18bdf4df3422d0
来源数据集
uspto-grants-2008_11
专利号
US07449468B2

关联笔记

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