氯乙酰氯 → Chloroacetic acid morpholine carboxamide

HRID 2703

反应方程式

HRID 2703 反应方程式
[Cl:1][CH2:2][C:3](Cl)=[O:4].C[N:7]1CC[O:10]CC1.[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>ClCCl>[N:13]1([C:3]([NH2:7])=[O:4])[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1.[Cl:1][CH2:2][C:3]([OH:4])=[O:10]

参与物

5

反应物 3

HCID 6577氯乙酰氯HCID 7972N-甲基吗啉HCID 80831,4-氧氮六环

产物 1

HCID 88103447Chloroacetic acid morpholine carboxamide

试剂、催化剂与溶剂 1

HCID 6344二氯甲烷溶剂

实验过程

Combine chloroacetyl chloride (2.00 mL, 25.0 mmol) and N-methylmorpholine (2.76 mL, 25.0 mmol) in dichloromethane (100 mL). Cool in an ice-bath. Add morpholine (2.19 mL, 25.0 mmol) and stir in the ice-bath for 1 hour. Warm to ambient temperature and stir for 1 hour. Extract with cold aqueous 5% sulfuric acid solution, saturated aqueous sodium bicarbonate solution, and saturated aqueous sodium chloride solution. Dry the organic layer over Na2SO4, filter, and evaporate in vacuo to obtain chloroacetic acid morpholine carboxamide.

后处理

  1. temperatureCool in an ice-bath
  2. extractionExtract with cold aqueous 5% sulfuric acid solution, saturated aqueous sodium bicarbonate solution, and saturated aqueous sodium chloride solution
  3. dry with materialDry the organic layer over Na2SO4
  4. filtrationfilter
  5. customevaporate in vacuo

来源与证据

ORD记录
ord-76b9fb90e765478eb9f07bde4c5ac1d8
来源数据集
uspto-grants-1998_03
专利号
US05731306

关联笔记

加载中…