化工社化工社化学信息打印报告 · 仅供科研参考
C.I.酸性橙108 → 2-(4-Nitrophenylimino)-3,5-diisobutyl-1,3-thiazolidine
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | C.I.酸性橙108 | HCID 700 | — |
| 反应物 | 异丁胺盐酸盐 | HCID 21133 | — |
| 反应物 | L-亮氨酸甲酯 | HCID 65105 | — |
| 反应物 | 异硫代氰基4-硝基苯酯 | HCID 75044 | — |
| 反应物 | L-亮氨醇 | HCID 111307 | — |
| 反应物 | (2S)-4-methyl-2-(isobutylamino)pentanol | HCID 22951222 | — |
| 产物 | 2-(4-Nitrophenylimino)-3,5-diisobutyl-1,3-thiazolidine | HCID 18316505 | — |
反应步骤
(1S)-1-(Hydroxymethyl)-3-methylbutylamine was made from (L)-leucine methyl ester as described in Method B1b. The 2-hydroxyethylamine was converted to (2S)-4-methyl-2-(isobutylamino)pentanol as described in Method B4c, Steps 1-2. The alcohol was converted to N-(1S)-1-(chloromethyl)-3-methylbutyl)-N-(isobutyl)ammonium chloride as described in Method B7c. 4-Nitrophenyl isothiocyanate was reacted with N-(1S)-1-(chloromethyl)-3-methylbutyl)-N-(isobutyl)ammonium chloride according to Method C1f to give 2-(4-nitrophenylimino)-3,5-diisobutyl-1,3-thiazolidine.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US06353006B1 |
| 来源数据集 | uspto-grants-2002_03 |
| ORD ID | ord-fca18c3d6f2b45a09b90cc168c051360 |
| 来源说明 | uspto-grants-2002_03 |