乙醛酸 → 4-羟基扁桃酸

HRID 278530

反应方程式

HRID 278530 反应方程式
[C:1]([OH:5])(=[O:4])[CH:2]=[O:3].[C:6]1([OH:12])[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>O>[OH:12][C:6]1[CH:11]=[CH:10][C:9]([CH:2]([OH:3])[C:1]([OH:5])=[O:4])=[CH:8][CH:7]=1

参与物

4

反应物 2

HCID 760乙醛酸HCID 996苯酚

产物 1

HCID 3284-羟基扁桃酸

试剂、催化剂与溶剂 1

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]溶剂

实验过程

The European patent specification EP-0,368,696 describes the condensation of a glyoxylic acid with phenol in the presence of a water-insoluble amine, to form a 12:84 mixture of 2- and 4-hydroxymandelic acid respectively. Then the excess of phenol is extracted with 1,1-dimethyl-1-methoxypropane. Only 70-74% of the paraisomer, 4-hydroxymandelic acid, is isolated leaving a non-separable mixture of approximately 1:1 2- and 4-hydroxymandelic acid.

后处理

  1. customto form
  2. extractionThen the excess of phenol is extracted with 1,1-dimethyl-1-methoxypropane

来源与证据

ORD记录
ord-89b113ed39194d25bd2436f24bca2c8a
来源数据集
uspto-grants-2002_03
专利号
US06359172B1

关联笔记

加载中…