二甲胺 → N,N-二甲基乙酰基乙酰胺

HRID 2851

反应方程式

HRID 2851 反应方程式
[CH2:1]=[C:2]1[O:6][C:4](=[O:5])[CH2:3]1.CC(C)=O.[CH3:11][NH:12][CH3:13]>C1(C)C=CC=CC=1>[CH3:11][N:12]([CH3:13])[C:4](=[O:5])[CH2:3][C:2](=[O:6])[CH3:1]

参与物

4

反应物 2

HCID 674二甲胺HCID 87118046Diketene acetone

产物 1

HCID 16278N,N-二甲基乙酰基乙酰胺

试剂、催化剂与溶剂 1

HCID 1140甲苯溶剂

实验过程

A solution of 9 ml (0.05 mmol) of diketene-acetone adduct in 20 ml of toluene was treated with gaseous dimethylamine at room temperature until the reaction was complete. The solvent was removed in vacuo and the residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→10%) yielding 7.0 g of the title compound.

后处理

  1. customThe solvent was removed in vacuo
  2. customthe residue was purified by chromatography on silica gel (EtOAc/MeOH 0%→10%)

来源与证据

ORD记录
ord-eb592b1203c74e969732293b7513ee02
来源数据集
uspto-grants-1998_03
专利号
US05731322

关联笔记

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