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碘化钾 → (+/-)-trans-2-Butyl-4a-(3-methoxyphenyl)-6-oxo-1,2,3,4,4a,5,6,7,8, 8a-decahydroisoquinoline
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 碘化钾 | HCID 4875 | — |
| 反应物 | 溴丁烷 | HCID 8002 | — |
| 反应物 | 碳酸钾 | HCID 11430 | — |
| 反应物 | (+/-)-trans-4a-(3-Methoxyphenyl)-6-oxo-1,2,3,4,4a,5,6,7,8, 8a-decahydroisoquinoline hydrochloride | HCID 86752321 | — |
| 溶剂 | N,N-二甲基甲酰胺 | HCID 6228 | — |
| 产物 | (+/-)-trans-2-Butyl-4a-(3-methoxyphenyl)-6-oxo-1,2,3,4,4a,5,6,7,8, 8a-decahydroisoquinoline | HCID 86752323 | 24.9% |
反应步骤
0.71 g (2.55 mmol) of (±)-trans-4a-(3-methoxyphenyl)-6-oxo-1,2,3,4,4a,5,6,7,8, 8a-decahydroisoquinoline hydrochloride, 0.37 g (2.68 mmol) of butyl bromide, 0.53 g of potassium carbonate and a catalytical amount of potassium iodide in 15 ml of DMF were reacted as described in preparation 20, yielding 0.2 g of the title compound which was used as such in the subsequent step.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US05731322 |
| 来源数据集 | uspto-grants-1998_03 |
| ORD ID | ord-9cef4a5077a74084b0f66091336f0c5e |
| 来源说明 | uspto-grants-1998_03 |