氰化钾 → 4-(7-Methoxy-1-naphthyl)butyronitrile

HRID 2888

反应方程式

HRID 2888 反应方程式
[C-:1]#[N:2].[K+].S(O[CH2:9][CH2:10][CH2:11][C:12]1[C:21]2[C:16](=[CH:17][CH:18]=[C:19]([O:22][CH3:23])[CH:20]=2)[CH:15]=[CH:14][CH:13]=1)(=O)(=O)C>CS(C)=O>[CH3:23][O:22][C:19]1[CH:20]=[C:21]2[C:16]([CH:15]=[CH:14][CH:13]=[C:12]2[CH2:11][CH2:10][CH2:9][C:1]#[N:2])=[CH:17][CH:18]=1

参与物

4

反应物 2

HCID 9032氰化钾HCID 153368673-(7-Methoxy-1-naphthyl)propyl mesylate

产物 1

HCID 153368684-(7-Methoxy-1-naphthyl)butyronitrile

试剂、催化剂与溶剂 1

HCID 679二甲基亚砜溶剂

实验过程

In a 100-cm3 flask, the 3-(7-methoxy-1-naphthyl)propyl mesylate obtained in stage D is dissolved in DMSO. KCN is added and the mixture is brought to reflux for 2 h. It is allowed to cool. It is poured into a water/ice mixture. The resulting mixture is extracted with ether. The organic phase is washed with water, dried over CaCl2 and evaporated. The product obtained is recrystallized.

后处理

  1. temperatureto reflux for 2 h
  2. temperatureto cool
  3. extractionThe resulting mixture is extracted with ether
  4. washThe organic phase is washed with water
  5. dry with materialdried over CaCl2
  6. customevaporated
  7. customThe product obtained
  8. customis recrystallized

来源与证据

ORD记录
ord-ebf01e6b38bc42c089b9940d05b2423f
来源数据集
uspto-grants-1998_03
专利号
US05731352

关联笔记

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