参与物
| 角色 | 名称 | HCID | 投料 |
|---|
| 反应物 | 哌啶-4-甲酰胺 | HCID 3772 | — |
| 反应物 | 间溴苯甲醚 | HCID 16971 | — |
| 试剂 | 双三甲基硅基胺基锂 | HCID 2733832 | — |
| 催化剂 | 醋酸钯 | HCID 4144353 | — |
| 催化剂 | 2,8,9-三异丁基-2,5,8,9-四氮杂-1-磷酸双向环[3.3.3]十一烷 | HCID 4571243 | — |
| 溶剂 | 甲苯 | HCID 1140 | — |
| 产物 | 1-(3-Methoxyphenyl)piperidine-4-carboxamide | HCID 10609747 | 0% |
反应步骤
piperidine-4-carboxamide (0.411 g, 3.21 mmol); 1-bromo-3-methoxybenzene (0.339 mL, 2.67 mmol) and diacetoxypalladium (0.120 g, 0.53 mmol) were thoroughly placed under an inert atmoshere. To this was added 2,8,9-triisobutyl-2,5,8,9-tetraaza-1-phosphabicyclo[3.3.3]undecane (0.037 g, 0.11 mmol); LITHIUM BIS(TRIMETHYLSILYL)AMIDE (6.15 mL, 6.15 mmol) and toluene (10 mL). The resultant mixture was stirred at 100 °C overnight. No sign of reaction by LCMS overnight. Abandoned
来源与证据
| 来源数据集 | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-c91f5415f0604adda8f4b73dd97ab0f8 |
|---|
| 来源说明 | 750 AstraZeneca ELN dataset |
|---|
