N-甲基吗啉氧化物 → 4-Phenyl-3-furaldehyde

HRID 326364

反应方程式

HRID 326364 反应方程式
[C:1]1([C:7]2[C:8]([CH2:12][OH:13])=[CH:9][O:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C[N+]1([O-])CCOCC1>ClCCl.[Ru]([O-])(=O)(=O)=O.C([N+](CCC)(CCC)CCC)CC>[C:1]1([C:7]2[C:8]([CH:12]=[O:13])=[CH:9][O:10][CH:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参与物

5

反应物 2

HCID 82029N-甲基吗啉氧化物HCID 15037154(4-Phenylfuran-3-yl)methanol

产物 1

HCID 150371484-Phenyl-3-furaldehyde

试剂、催化剂与溶剂 2

HCID 178419074HCID 178419074，化合物催化剂HCID 6344二氯甲烷溶剂

实验过程

A mixture of 4-phenyl-3-furanmethanol (458 mg, 2.63 mmol), powdered 4A molecular sieves (500 mg), 4-methyl-morpholine-N-oxide (462 mg, 3.95 mmol) and tetrapropylammonium perruthenate (46 mg, 0.13 mmol) in anhydrous dichloromethane (40 ml) were stirred at room temperature for 3 hours. Residue was filtered through silica and concentrated to a brown oil which was purified by flash chromatography on silica using 10% ethyl ether/hexanes to give the titled aldehyde.

后处理

  1. filtrationResidue was filtered through silica
  2. concentrationconcentrated to a brown oil which
  3. customwas purified by flash chromatography on silica using 10% ethyl ether/hexanes

来源与证据

ORD记录
ord-ddae1b59dc504507827b5d46a07023df
来源数据集
uspto-grants-1993_12
专利号
US05268387

关联笔记

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