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对羟基苯甲酸 → Benzoic acid, 4-hydroxy-, 2-methylbutyl ester
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 对羟基苯甲酸 | HCID 135 | — |
| 反应物 | 四氧化硫 | HCID 1118 | — |
| 反应物 | S-(-)-2-甲基-1-丁醇 | HCID 2723602 | — |
| 溶剂 | 甲苯 | HCID 1140 | — |
| 产物 | Benzoic acid, 4-hydroxy-, 2-methylbutyl ester | HCID 13530949 | 88.1% |
反应步骤
0.29 mol (40.0 g) of p-hydroxybenzoic acid and 0.35 mol (30.9 g) of (S)-(-)-2-methylbutanol were refluxed for 20 hours in 150 ml of toluene in the presence of 1 ml of concentrated sulfuric acid. The reaction solution was concentrated and then purified by column chromatography to obtain 53.2 g of 2-methylbutyl p-hydroxybenzoate [[α]D23 =+4.95° (CHCl3)]. (Yield: 88%)
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US05271866 |
| 来源数据集 | uspto-grants-1993_12 |
| ORD ID | ord-fb733aa1afc94062adf93246407db853 |
| 来源说明 | uspto-grants-1993_12 |