甲基磺酰氯 → 2-(2-Fluorophenyl)ethyl methanesulfonate

HRID 331238

反应方程式

HRID 331238 反应方程式
[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[CH:7][C:3]=1[CH2:4][CH2:5][OH:6].[CH3:11][S:12](Cl)(=[O:14])=[O:13]>C(N(CC)CC)C.C(Cl)Cl>[CH3:11][S:12]([O:6][CH2:5][CH2:4][C:3]1[CH:7]=[CH:8][CH:9]=[CH:10][C:2]=1[F:1])(=[O:14])=[O:13]

参与物

5

反应物 2

HCID 31297甲基磺酰氯HCID 27332962-氟苯乙醇

产物 1

HCID 151245352-(2-Fluorophenyl)ethyl methanesulfonate

试剂、催化剂与溶剂 2

HCID 6344二氯甲烷溶剂HCID 8471三乙胺溶剂

实验过程

To a solution of 2-fluorophenethylalcohol (25.0 g) in triethylamine (37.5 ml) and methylene chloride (250 ml) was added dropwise methanesulfonyl chloride (16.7 ml) under ice-cooling, and the mixture was stirred for 30 min. The reaction mixture was warmed to room temperature, washed with water and saturated brine, dried over anhydrous magnesium sulfate, and concentrated to give 2-(2-fluorophenyl)ethyl methanesulfonate.

后处理

  1. temperaturecooling
  2. washwashed with water and saturated brine
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated

来源与证据

ORD记录
ord-c1a992d32f7e4db4abea21507bf12076
来源数据集
uspto-grants-2014_11
专利号
US08877779B2

关联笔记

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