参与物
| 角色 | 名称 | HCID | 投料 |
|---|
| 反应物 | 三氟乙酸 | HCID 6422 | — |
| 反应物 | N,N-二异丙基乙胺 | HCID 81531 | — |
| 反应物 | 顺式-1,2-环己二胺 | HCID 342917 | — |
| 反应物 | 3-(1H-indazol-5-ylamino)-5-chloropyrazine-2-carboxamide | HCID 86685602 | — |
| 溶剂 | 聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯] | HCID 962 | — |
| 溶剂 | N-甲基吡咯烷酮 | HCID 13387 | — |
| 产物 | cis-3-(1H-indazol-5-ylamino)-5-(2-aminocyclohexylamino)pyrazine-2-carboxamide | HCID 86685601 | — |
反应步骤
To 3-(1H-indazol-5-ylamino)-5-chloropyrazine-2-carboxamide (˜100 mg) in ˜3 mL NMP was added 6 equivalents of DIEA and 20 equivalents of racemic cis-1,2-cyclohexanediamine. The mixture was heated at 150° C. in a sealed tube overnight. The reaction mixture was cooled, acidified with TFA, diluted with water and prepped via rpHPLC to give the title compound. MS found for C18H22N8O as (M+H)+ 367.2.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 专利号 | US08877760B2 |
|---|
| 来源数据集 | uspto-grants-2014_11 |
|---|
| ORD ID | ord-a19ccca8d35144f0804de074e685fe15 |
|---|
| 来源说明 | uspto-grants-2014_11 |
|---|
