二氯甲烷 → N-(6-Cyanohexanoyl)glycine, ethyl ester

HRID 3335

反应方程式

HRID 3335 反应方程式
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([NH:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:8].[C-:16]#[N:17].[K+].ClCCl>C(O)C>[C:16]([CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][C:7]([NH:9][CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])=[O:8])#[N:17]

参与物

5

反应物 3

HCID 6344二氯甲烷HCID 9032氰化钾HCID 86154941N-(6-bromohexanoyl)-glycine, ethyl ester

产物 1

HCID 85707690N-(6-Cyanohexanoyl)glycine, ethyl ester收率 99%

试剂、催化剂与溶剂 1

HCID 702乙醇溶剂

实验过程

23.73 g (84.7·10-3 mol) of N-(6-bromohexanoyl)-glycine, ethyl ester are dissolved in 200 ml of ethanol, and 6.5 g (0.1 mol) of powdered potassium cyanide are added. The reaction mixture is brought to the reflux point and stirred under reflux for 15 hours. After concentration of the mixture under reduced pressure, the residue is taken up with dichloromethane and the organic phase is washed with aqueous sodium chloride solution. The organic phase is dried and concentrated under reduced pressure to give 19 g of the expected product (yield=99%).

后处理

  1. temperatureunder reflux for 15 hours
  2. washthe organic phase is washed with aqueous sodium chloride solution
  3. customThe organic phase is dried
  4. concentrationconcentrated under reduced pressure

来源与证据

ORD记录
ord-f0e0f1638dcd40c780aa7d8ec6375945
来源数据集
uspto-grants-1998_03
专利号
US05733928

关联笔记

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