1,4-氧氮六环 → Acetic Acid 5-(morpholin-4-yl)methyl-furan-2-ylmethyl Ester

HRID 34118

反应方程式

HRID 34118 反应方程式
[C:1]([O:4][CH2:5][C:6]1[O:10][C:9]([CH:11]=O)=[CH:8][CH:7]=1)(=[O:3])[CH3:2].[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+]>ClCCCl.ClCCl>[N:13]1([CH2:11][C:9]2[O:10][C:6]([CH2:5][O:4][C:1](=[O:3])[CH3:2])=[CH:7][CH:8]=2)[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1

参与物

6

反应物 3

HCID 80831,4-氧氮六环HCID 663495-乙酰氧基甲基-2-呋喃醛HCID 5049666三乙酰氧基硼氢化钠

产物 1

HCID 14568660Acetic Acid 5-(morpholin-4-yl)methyl-furan-2-ylmethyl Ester

试剂、催化剂与溶剂 2

HCID 111,2-二氯乙烷溶剂HCID 6344二氯甲烷溶剂

实验过程

Under nitrogen atmosphere, to a solution of 2.0 g of 5-acetoxymethyl-2-furanaldehyde and 1.1 mL of morpholine in 35 mL of 1,2-dichloroethane was added 4.0 g of sodium triacetoxy borohydride at room temperature, and stirred at this temperature for 3 hours. The reaction solution was diluted with dichloromethane, washed successively with saturated aqueous sodium hydrogen carbonate and saturated brine, and then dried over anhydrous magnesium sulfate. The solvent was evaporated, and the residue was purified and separated by silica gel column chromatography, to afford 2.3 g of the title compound as a colorless oil.

后处理

  1. washwashed successively with saturated aqueous sodium hydrogen carbonate and saturated brine
  2. dry with materialdried over anhydrous magnesium sulfate
  3. customThe solvent was evaporated
  4. customthe residue was purified
  5. customseparated by silica gel column chromatography

来源与证据

ORD记录
ord-c408746cbab8470790f98487d756d10d
来源数据集
uspto-grants-2008_09
专利号
US07429609B2

关联笔记

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