3,4-二氢-2H-吡喃 → 2-[(3-Bromophenyl)methoxy]oxane

HRID 341985

反应方程式

HRID 341985 反应方程式
[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][OH:9])[CH:5]=[CH:6][CH:7]=1.[O:10]1[CH:15]=[CH:14][CH2:13][CH2:12][CH2:11]1.Br.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][O:9][CH:11]2[CH2:12][CH2:13][CH2:14][CH2:15][O:10]2)[CH:5]=[CH:6][CH:7]=1

参与物

5

反应物 3

HCID 80803,4-二氢-2H-吡喃HCID 80811Triphenylphosphonium bromideHCID 851413-溴苯甲醇

产物 1

HCID 152820642-[(3-Bromophenyl)methoxy]oxane

试剂、催化剂与溶剂 1

HCID 6344二氯甲烷溶剂

实验过程

The alcohol of Step 1 (41.23 mmol), dihydropyran (12.5 mL, 137 mmol) and triphenylphosphine hydrobromide (725 mg, 2.11 mmol) were mixed together in 200 mL of CH2Cl2 and stirred for 2 days. The solvent was then evaporated and the title product was purified by flash chromatography on silica using EtOAc:toluene.

后处理

  1. customThe solvent was then evaporated
  2. customthe title product was purified by flash chromatography on silica

来源与证据

ORD记录
ord-26550fcdd4ce4475a6345906644a73e3
来源数据集
uspto-grants-1999_01
专利号
US05856322

关联笔记

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