参与物
| 角色 | 名称 | HCID | 投料 |
|---|
| 反应物 | 6-Methoxy-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-ylamine | HCID 57512866 | — |
| 反应物 | (2R)-8-chloro-4-methyl-2-phenyl-3,5-dihydro-2H-pyrido[3,2-f][1,4]oxazepine | HCID 57512880 | — |
| 试剂 | 碳酸氢铯 | HCID 10796 | — |
| 催化剂 | 三叔丁基膦 | HCID 83681 | — |
| 催化剂 | 三(二亚苄基丙酮)二钯 | HCID 9811564 | — |
| 产物 | gamma-Secretase modulator 6 | HCID 49819500 | 0% |
反应步骤
Charged a standard microwave vial with a mixture of 6-methoxy-5-(1-methyl-1H-pyrazol-4-yl)pyridin-2-amine (100 mg, 0.49 mmol), (R)-8-chloro-4-methyl-2-phenyl-2,3,4,5-tetrahydropyrido[3,2-f][1,4]oxazepine (135 mg, 0.49 mmol), cesium carbonate (239 mg, 0.73 mmol), TRIS(DIBENZYLIDENEACETONE)DIPALLADIUM(0) (22.42 mg, 0.02 mmol), Tri-tert- butylphosphonium tetrafluoroborate (14.21 mg, 0.05 mmol), and 1,2-dimethoxyethane. The atmosphere was inerted through vacuum-nitrogen cycles and the contents were heated at 120 °C for a period of 30 min. LCMS indicates reaction progression is less than 10%. Reaction aborted. Not progressed.
来源与证据
| 来源数据集 | 750 AstraZeneca ELN dataset |
|---|
| ORD ID | ord-f55732d796df4a6bad136ec929c58223 |
|---|
| 来源说明 | 750 AstraZeneca ELN dataset |
|---|
