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对甲苯磺酸 → 4'-[(S)-2-methylbutoxycarbonyl]biphenyl-4-ol
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 对甲苯磺酸 | HCID 6101 | — |
| 反应物 | 4'-羟基联苯-4-羧酸 | HCID 301556 | — |
| 反应物 | S-(-)-2-甲基-1-丁醇 | HCID 2723602 | — |
| 产物 | 4'-[(S)-2-methylbutoxycarbonyl]biphenyl-4-ol | HCID 13907538 | 41% |
反应步骤
3.75 g of 4-hydroxybiphenyl-4'-carboxylic acid was heated under reflux together with (S)-2-methylbutyl alcohol in the presence of 0.10 g of p-toluenesulfonic acid for about 6 hours. Then the mixture was filtered to remove the unreacted 4-hydroxybiphenyl-4'-carboxylic acid. Next, the filtrate was evaporated and the unreacted (S)-2-methylbutyl alcohol was distilled off. The crystals thus obtained were recrystallized from 200 ml of n-hexane. Thus, 2.05 g of the corresponding colorless compound was obtained (Yield: 41%).
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US05055225 |
| 来源数据集 | uspto-grants-1991_10 |
| ORD ID | ord-cf17dec162e3440886c834555d7b68d0 |
| 来源说明 | uspto-grants-1991_10 |