RMA03230对照品 → 4,5-Dichlorotetrahydrophthalic anhydride

HRID 345958

反应方程式

HRID 345958 反应方程式
[Cl:1][C:2]([C:4]([Cl:6])=[CH2:5])=[CH2:3].[C:7]1(=[O:13])[O:12][C:10](=[O:11])[CH:9]=[CH:8]1>C1(C)C=CC=CC=1>[Cl:1][CH:2]1[C:4]([Cl:6])=[CH:5][CH:9]2[C:10]([O:12][C:7](=[O:13])[CH:8]2[CH2:3]1)=[O:11]

参与物

4

反应物 2

HCID 7923RMA03230对照品HCID 154472,3-Dichloro-1,3-butadiene

产物 1

HCID 541398954,5-Dichlorotetrahydrophthalic anhydride收率 61.8%

试剂、催化剂与溶剂 1

HCID 1140甲苯溶剂

实验过程

A 500 mL reaction flask was charged with 34.5 g of 2,3-dichlorobutadiene and 27.5 g of maleic anhydride. 200 mL of toluene was added, along with a small amount of BHT (0.5 g). The solution was heated to reflux until the reaction was complete. The toluene was removed and the product recrystallized from ethyl acetate/hexanes to give 38.25 g (61.8%) of 4,5-dichlorotetrahydrophthalic anhydride.

后处理

  1. customA 500 mL reaction flask
  2. temperatureThe solution was heated
  3. temperatureto reflux until the reaction
  4. customThe toluene was removed
  5. customthe product recrystallized from ethyl acetate/hexanes

来源与证据

ORD记录
ord-97799dd1ebef4fde987c5935e4a800db
来源数据集
uspto-grants-1991_10
专利号
US05059697

关联笔记

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