2,6-二甲基苯胺 → N-(2,6-dimethylphenyl)-2-(4-oxo-3-thiazolidinyl)propionamide

HRID 34908

反应方程式

HRID 34908 反应方程式
[O:1]=[C:2]1[CH2:6][S:5][CH2:4][N:3]1[CH:7]([CH3:11])[C:8]([OH:10])=O.[CH3:12][C:13]1[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[C:14]=1[NH2:15].C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)(Cl)Cl>[CH3:12][C:13]1[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[C:14]=1[NH:15][C:8](=[O:10])[CH:7]([N:3]1[C:2](=[O:1])[CH2:6][S:5][CH2:4]1)[CH3:11]

参与物

5

反应物 3

HCID 68962,6-二甲基苯胺HCID 10868N,N'-二环己基碳二亚胺HCID 232453502-(4-Oxo-3-thiazolidinyl)propionic acid

产物 1

HCID 13853984N-(2,6-dimethylphenyl)-2-(4-oxo-3-thiazolidinyl)propionamide收率 45.7%

试剂、催化剂与溶剂 1

HCID 6212三氯甲烷溶剂

实验过程

A mixture of 2-(4-oxo-3-thiazolidinyl)propionic acid (2.00 g), 2.6-dimethylaniline (1.38 g), and dicyclohexylcarbodiimide (2.35 g) in chloroform (15 ml) was refluxed for 48 hours. The resultant precipitate was removed by filtration and the filtrate was evaporated in vacuo. The residue was triturated with diethyl ether and recrystallized from ethanol to give N-(2,6-dimethylphenyl)-2-(4-oxo-3-thiazolidinyl)propionamide (1.45 g) as colorless prisms.

后处理

  1. temperaturewas refluxed for 48 hours
  2. customThe resultant precipitate was removed by filtration
  3. customthe filtrate was evaporated in vacuo
  4. customThe residue was triturated with diethyl ether
  5. customrecrystallized from ethanol

来源与证据

ORD记录
ord-6a9aab5ee7f74d7c9c9deececbc2446a
来源数据集
uspto-grants-1988_08
专利号
US04764514

关联笔记

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