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(S)-(-)-1-苯丙胺 → (S)-N-(alpha-Ethylbenzyl)-3-methyl-7-methoxy-2-phenylquinoline-4-carboxamide
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | (S)-(-)-1-苯丙胺 | HCID 6993773 | — |
| 反应物 | 3-Methyl-7-methoxy-2-phenylquinoline-4-carbonylchloride | HCID 22714324 | — |
| 溶剂 | N,N-二甲基甲酰胺 | HCID 6228 | — |
| 溶剂 | 二氯甲烷 | HCID 6344 | — |
| 产物 | (S)-N-(alpha-Ethylbenzyl)-3-methyl-7-methoxy-2-phenylquinoline-4-carboxamide | HCID 53800998 | — |
反应步骤
Prepared as described in Ex. 1, starting from 1.27 g (4.09 mmol) of crude 3-methyl-7-methoxy-2-phenylquinoline-4-carbonylchloride, 0.55 g (4.09 mmol) of (S)-(−)-α-ethylbenzylamine and 1.71 ml (12.27 mmol) of TEA in 24 ml of dry CH2Cl2 and 1 ml of DMF to help solubility. The reaction mixture was stirred 12 hours at room temperture.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US06743804B2 |
| 来源数据集 | uspto-grants-2004_06 |
| ORD ID | ord-6b6d42c8181744128124c7ceaab1b7a8 |
| 来源说明 | uspto-grants-2004_06 |