十八烯 → 3-(4-Methoxyphenyl)-3-(1H-1,2,4-triazol-1-ylmethyl)-2-methyl-5-n-octylisoxazolidine

HRID 35740

反应方程式

HRID 35740 反应方程式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[N+:16]([O-:18])[CH3:17])[CH2:10][N:11]2[CH:15]=[N:14][CH:13]=[N:12]2)=[CH:5][CH:4]=1.[CH2:19]=[CH:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]CCCCCCCC>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2([CH2:10][N:11]3[CH:15]=[N:14][CH:13]=[N:12]3)[CH2:19][CH:20]([CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[O:18][N:16]2[CH3:17])=[CH:5][CH:4]=1

参与物

3

反应物 2

HCID 8217十八烯HCID 727284571-(4-methoxyphenyl)-N-methyl-2-(1H-1,2,4-triazol-1-yl)ethanimine N-oxide

产物 1

HCID 143264433-(4-Methoxyphenyl)-3-(1H-1,2,4-triazol-1-ylmethyl)-2-methyl-5-n-octylisoxazolidine

实验过程

Derivative 3 (R=4-OCH3, n=7) is prepared by a procedure similar to that described in Example 1 by reacting 1-(4-methoxyphenyl)-N-methyl-2-(1H-1,2,4-triazol-1-yl)ethanimine N-oxide (1: R=4-OCH3) with 1-decene (2: n=7). The resulting diastereomeric mixture of cis- and trans-derivative 3 (R=4-OCH3, n=7) is flash-chromatographed on neutral silica gel using chloroform-methanol (99:1 by volume) as eluent. Isomer A has a melting point of 89°-91° C. (ethyl acetate).

后处理

  1. customDerivative 3 (R=4-OCH3, n=7) is prepared by a procedure similar to
  2. additionThe resulting diastereomeric mixture of cis- and trans-derivative 3 (R=4-OCH3, n=7)
  3. customis flash-chromatographed on neutral silica gel

来源与证据

ORD记录
ord-df12137694794b8fbee01f301f5614e3
来源数据集
uspto-grants-1988_08
专利号
US04767866

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