化工社化工社化学信息打印报告 · 仅供科研参考
氢化钠 → 喹螨醚
参与物
| 角色 | 名称 | HCID | 投料 |
|---|---|---|---|
| 反应物 | 氢化钠 | HCID 24758 | — |
| 反应物 | 4-氯喹唑啉 | HCID 78864 | — |
| 反应物 | 4-叔丁基苯乙醇 | HCID 79410 | — |
| 溶剂 | 聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯] | HCID 962 | — |
| 溶剂 | N,N-二甲基甲酰胺 | HCID 6228 | — |
| 产物 | 喹螨醚 | HCID 86356 | 28.4% |
反应步骤
To a solution of 1.1 g of sodium hydride in 50 ml of DMF, 4.0 g of 2-[4-(t-butyl)phenyl]ethanol was added, and the mixture was stirred at room temperature for one hour. Then 3.6 g of 4-chloroquinazoline in 20 ml of DMF were added, and the mixture was stirred at room temperature overnight. The mixture was then poured into a mixture of ice in water. The product was extracted into CH2Cl2, and the resulting solution was concentrated to dryness. TLC showed one major spot and five minor spots. The product was purified by HPLC (silica gel, CH2Cl2). The fractions containing the major product were collected and concentrated, giving 1.9 g of the title product. Yield: 28.4%. M.P. 70°-71° C.
来源与证据
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 专利号 | US05411963 |
| 来源数据集 | uspto-grants-1995_05 |
| ORD ID | ord-378409998bb94c5480b3bbf142ebb392 |
| 来源说明 | uspto-grants-1995_05 |