三溴化磷 → 3-氯苄溴

HRID 36340

反应方程式

HRID 36340 反应方程式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5]O.P(Br)(Br)[Br:11]>O1CCCC1>[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH2:5][Br:11]

参与物

4

反应物 2

HCID 24614三溴化磷HCID 701173-氯苯甲醇

产物 1

HCID 698383-氯苄溴

试剂、催化剂与溶剂 1

HCID 8028四氢呋喃溶剂

反应条件

温度
0 °C

实验过程

A solution of 260 ul of 3-chlorobenzyl alcohol dissolved in 2.5 ml of dry tetrahydrofuran is cooled to 0° C. and 120 ul of PBr3 added. The reaction is stirred for 3 hours and extracted with ether. The organic layer is washed with saturated sodium bicarbonate and evaporated to give the desired product.

后处理

  1. extractionextracted with ether
  2. washThe organic layer is washed with saturated sodium bicarbonate
  3. customevaporated

来源与证据

ORD记录
ord-2e356bec6541419499a7e4e5503f2522
来源数据集
uspto-grants-1995_05
专利号
US05414001

关联笔记

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