氟化钠 → Ethyl 5,6,7,8-tetrafluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylate

HRID 36706

反应方程式

HRID 36706 反应方程式
F[C:2]1[C:25]([F:26])=[C:24]([F:27])[C:23]([F:28])=[C:22](F)[C:3]=1[C:4]([C:6](=[CH:12][NH:13][C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=1[F:21])[C:7]([O:9][CH2:10][CH3:11])=[O:8])=[O:5].[F-:30].[Na+]>CN(C)C=O>[F:30][C:22]1[C:23]([F:28])=[C:24]([F:27])[C:25]([F:26])=[C:2]2[C:3]=1[C:4](=[O:5])[C:6]([C:7]([O:9][CH2:10][CH3:11])=[O:8])=[CH:12][N:13]2[C:14]1[CH:19]=[CH:18][C:17]([F:20])=[CH:16][C:15]=1[F:21]

参与物

4

反应物 2

HCID 5235氟化钠HCID 178471933HCID 178471933，化合物

产物 1

HCID 15070037Ethyl 5,6,7,8-tetrafluoro-1-(2,4-difluorophenyl)-1,4-dihydro-4-oxo-3-quinolinecarboxylate收率 94.6%

试剂、催化剂与溶剂 1

HCID 6228N,N-二甲基甲酰胺溶剂

实验过程

A mixture of 135.4 g of ethyl 2-(2,3,4,5,6-pentafluorobenzoyl)-3-(2,4-difluorophenylamino)acrylate, 20.6 g of sodium fluoride and 300 ml of anhydrous dimethylformamide is heated at 140°-150° C. for 3 hours. The suspension is poured hot onto 2 kg of ice and the precipitate is filtered off with suction, washed with water and dried. 122 g of the title compound of melting point 160°-162° C. are obtained.

后处理

  1. temperatureis heated at 140°-150° C. for 3 hours
  2. filtrationthe precipitate is filtered off with suction
  3. washwashed with water
  4. customdried

来源与证据

ORD记录
ord-a7a8b79b7c704589858ff17f00b1b43c
来源数据集
uspto-grants-1995_05
专利号
US05416096

关联笔记

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