聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯] → N-(4-phenylcyclohexyl)-N-cyclohexylmethylamine

HRID 37295

反应方程式

HRID 37295 反应方程式
[C:1]1([CH:7]2[CH2:12][CH2:11][C:10](=O)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH:14]1([CH2:20][NH2:21])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1.O>C1C=CC=CC=1>[C:1]1([CH:7]2[CH2:12][CH2:11][CH:10]([NH:21][CH2:20][CH:14]3[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]3)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参与物

5

反应物 3

HCID 962聚[6-[4-(4-氰基苯基)苯氧基]己基甲基丙烯酸酯]HCID 76688环己甲胺HCID 786054-苯基环己酮

产物 1

HCID 19935094N-(4-phenylcyclohexyl)-N-cyclohexylmethylamine

试剂、催化剂与溶剂 1

HCID 241苯溶剂

实验过程

A solution of 5 g of 4-phenylcyclohexanone and cyclohexylmethylamine in 100 ml of benzene was refluxed for 2 hours with removing water and the solvent was distilled away in vacuo. The residue was dissolved in methanol and to the solution was added 1.5 g of sodium borohydride. The mixture was stirred at room temperature and the solvent was distilled away in vacuo. To the residue was added water and extracted with diethyl ether. The organic layer was washed with saturated brine and dried over magnesium sulfate. The solvent was distilled away to give 7 g of N-(4-phenylcyclohexyl)-N-cyclohexylmethylamine as an oil. (N-(4-phenylcyclohexyl)-N-cyclohexylmethylamine hydrochloride, melting at 267°-270° C. with decomposition)

后处理

  1. distillationthe solvent was distilled away in vacuo
  2. dissolutionThe residue was dissolved in methanol and to the solution
  3. additionwas added 1.5 g of sodium borohydride
  4. distillationthe solvent was distilled away in vacuo
  5. additionTo the residue was added water
  6. extractionextracted with diethyl ether
  7. washThe organic layer was washed with saturated brine
  8. dry with materialdried over magnesium sulfate
  9. distillationThe solvent was distilled away

来源与证据

ORD记录
ord-8915cbe5c8664ef18622aa95456bc4f5
来源数据集
uspto-grants-1995_05
专利号
US05420164

关联笔记

加载中…