反应方程式
[CH:1]1[CH:2]=[CH:3][C:4]2N(O)N=[N:7][C:5]=2C=1.CCN([CH:17]([CH3:19])C)C(C)C.CN([C:23]([O:27]N1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[Br:44]C1C(C(O)=O)=NC=CC=1.N1C=CN2CCNCC=12.[CH3:63][N:64]([CH:66]=[O:67])[CH3:65]>C(Cl)Cl>[Br:44][C:5]1[CH:4]=[CH:3][CH:2]=[C:1]([C:66]([N:64]2[CH2:65][CH2:19][C@@H:17]([O:27][CH3:23])[CH2:63]2)=[O:67])[N:7]=1参与物
8
反应物 6
产物 1
试剂、催化剂与溶剂 1
实验过程
A solution of HOBt (148 mg, 0.97 mmol), DIEA (130 μL, 0.74 mmol), HATU (367 mg, 0.97 mmol), bromopyridine-2-carboxylic acid (150 mg, 0.74 mmol) and 5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine (91 mg, 0.74 mmol) in DMF (2.5 mL) was stirred overnight at 65° C. Upon completion, Si-carbonate (2.8 g, 2.23 mmol) and DCM (3 mL) were added and the mixture was shaken overnight at room temperature. The resulting mixture was then filtered, washed with DCM, concentrated in vacuo and purified by reverse phase HPLC (acetonitrile/water+formic acid modifier) to afford the title compound.
后处理
- filtrationThe resulting mixture was then filtered
- washwashed with DCM
- concentrationconcentrated in vacuo
- custompurified by reverse phase HPLC (acetonitrile/water+formic acid modifier)
来源与证据
- ORD记录
- ord-ef6d136ec9034e4880c918885b1dd270
- 来源数据集
- uspto-grants-2013_02
- 专利号
- US08367706B2
关联笔记
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